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Infectious Disease: Coronavirus
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Total 80352 results found since Jan 2013.
GSE210497 SARS-CoV-2 pathogenesis mediated by E protein's PBM was prevented by modulators of CFTR function
Contributors : Jose M Honrubia ; Francisco J Guti érrez-Álvarez ; Alejandro Sanz ; Diego Muñoz ; Ezequiel González ; Carlos Castaño-Rodríguez ; Jorge Ripoll ; Ana Esteban ; Raúl Fernández-Delgado ; Juan C Oliveros ; Stanley Perlman ; Paul McCray ; Luis EnjuanesSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe three human deadly coronaviruses (CoVs) (SARS-CoV, MERS-CoV and SARS-CoV-2) have infected around eight thousand, two thousand six hundred and 262 million people so far (December 2021), causing the death of 10%, 37% and 2% of them, respectively, so their implication in h...
Source: GEO: Gene Expression Omnibus - September 22, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Viruses, Vol. 15, Pages 1976: Extracellular Vesicles as a Translational Approach for the Treatment of COVID-19 Disease: An Updated Overview
a Di Domenico
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a global pandemic in the years 2020–2022. With a high prevalence, an easy route of transmission, and a long incubation time, SARS-CoV-2 spread quickly and affected public health and socioeconomic conditions. Several points need to be elucidated about its mechanisms of infection, in particular, its capability to evade the immune system and escape from neutralizing antibodies. Extracellular vesicles (EVs) are phospholipid bilayer-delimited particles that are involved in cell-to-cell communication; they contain biological infor...
Source: Viruses - September 22, 2023 Category: Virology Authors: Enrica Serretiello Andrea Ballini Annafrancesca Smimmo Marina Acunzo Mariarosaria Raimo Stefania Cantore Marina Di Domenico Tags: Review Source Type: research
Viruses, Vol. 15, Pages 1975: Alterations in Patients & rsquo; Clinical Outcomes and Respiratory Viral Pathogen Activity following the COVID-19 Pandemic
Conclusions: We have demonstrated a reduction in the detection of several viruses, which might be due to the increase in public awareness toward infection protection measures after the COVID-19 pandemic.
Source: Viruses - September 22, 2023 Category: Virology Authors: Khaled Al Oweidat Ahmad A. Toubasi Ahmad Alghrabli Yasmeen Khater Noor Saleh Asma S. Albtoosh Rawan Shafeek Batarseh Tags: Article Source Type: research
SARS-CoV-2 egress from Vero cells: a morphological approach
This study aimed to shed light on the morphological features of SARS-CoV-2 egress by utilizing transmission and high-resolution scanning electron microscopy, along with serial electron tomography, to describe the route of nascent virions towards the extracellular medium. Electron microscopy revealed that the clusters of viruses in the paracellular space did not seem to result from collective virus release. Instead, virus accumulation was observed on incurved areas of the cell surface, with egress primarily occurring through individual vesicles. Additionally, our findings showed that the emission of long membrane projection...
Source: Histochemistry and Cell Biology - September 22, 2023 Category: Biomedical Science Source Type: research
The role of Pannexin-1 channels, ATP, and purinergic receptors in the pathogenesis of HIV and SARS-CoV-2
Curr Opin Pharmacol. 2023 Sep 19;73:102404. doi: 10.1016/j.coph.2023.102404. Online ahead of print.ABSTRACTInfectious agents such as human immune deficiency virus-1 (HIV) and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) use host proteins to infect, replicate, and induce inflammation within the host. A critical component of these diseases is the axis between pannexin-1 channels, extracellular ATP, and purinergic receptors. Here, we describe the potential therapeutic role of Pannexin-1/purinergic approaches to prevent or reduce the devastating consequences of these pathogens.PMID:37734241 | DOI:10.1016/j.coph.2023.102404
Source: Current Opinion in Pharmacology - September 21, 2023 Category: Drugs & Pharmacology Authors: Cristian A Hernandez Eliseo A Eugenin Source Type: research
Nervous system-related tropism of SARS-CoV-2 and autoimmunity in COVID-19 infection
This article is protected by copyright. All rights reserved.PMID:37733584 | DOI:10.1002/eji.202250230
Source: European Journal of Immunology - September 21, 2023 Category: Allergy & Immunology Authors: Robert Weissert Source Type: research
Bioactive lipid-based therapeutic approach to COVID-19 and other similar infections
Arch Med Sci. 2021 Apr 23;19(5):1327-1359. doi: 10.5114/aoms/135703. eCollection 2023.ABSTRACTCOVID-19 is caused by SARS-CoV-2 infection. Epithelial and T, NK, and other immunocytes release bioactive lipids especially arachidonic acid (AA) in response to microbial infections to inactivate them and upregulate the immune system. COVID-19 (coronavirus) and other enveloped viruses including severe acute respiratory syndrome (SARS-CoV-1 of 2002-2003) and Middle East respiratory syndrome (MERS; 2012-ongoing) and hepatitis B and C (HBV and HCV) can be inactivated by AA, γ-linolenic acid (GLA, dihomo-GLA (DGLA), eicosapentaenoic ...
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Undurti N Das Source Type: research
The effect of SARS-CoV-2 on the development of Parkinson's disease: the role of α-synuclein
AbstractThe current coronavirus disease 2019 (COVID-19) can lead to various neurological complications in infected people. These neurological effects include problems in both central nervous system (CNS) and peripheral nervous system (PNS). Hyposmia, a PNS symptom of COVID-19, frequently manifests in the early stages of Parkinson's disease (PD) and serves as an early warning sign of the condition. In addition, the olfactory system is recognized as an early site for the onset of α-synuclein pathology, the pathological hallmark of PD. PD is characterized by accumulation and aggregation of misfolded α-synuclein (α-Syn) int...
Source: Human Cell - September 21, 2023 Category: Cytology Source Type: research
Novel inflammatory biomarkers in the prognosis of COVID-19
CONCLUSIONS: In summary, this meta-analysis provides the most up-to-date and comprehensive evidence for the role of the mentioned novel inflammatory biomarkers in the prognosis of COVID-19, especially in evaluating death and other poor prognoses, with most biomarkers showing a better discriminatory ability.PMID:37727063 | DOI:10.1177/17534666231199679
Source: Adv Data - September 20, 2023 Category: Epidemiology Authors: Kegang Zhan Luhan Wang Hao Lin Xiaoyu Fang Hong Jia Xiangyu Ma Source Type: research
Neonatal erythema multiforme associated with a rotavirus infection: A case report
CONCLUSION: The possibility of rotavirus, a major cause of pediatric gastrointestinal infections, being a trigger for neonatal EM should be considered.PMID:37727716 | PMC:PMC10506005 | DOI:10.12998/wjcc.v11.i24.5749
Source: Herpes - September 20, 2023 Category: Infectious Diseases Authors: Jung Jae Kim Joon Kee Lee Source Type: research
Exploring the Access and Use of Social Technologies by Older Adults in Support of Their Mental Health During the COVID-19 Pandemic: A Rapid Review
This study aimed to explore the accessibility, outcomes, and challenges of social technology use among community-dwelling older adults, older adults in long-term care, older adults with neurocognitive disorder, and older adults with pre-frailty and frailty, to help guide future research in this area. A rapid review was conducted, and articles were retrieved from four online databases, including Medline, AgeLine, EconLit and CINAHL, and grey literature from Google Scholar. Of the 131 articles retrieved, 24 were included in this review. The positive outcomes of social technology use include improved mental and physical healt...
Source: Canadian Journal on Aging - September 20, 2023 Category: Geriatrics Authors: Joelle R DesCh âtelets Asif R Khowaja Kristin Mechelse Henriette Koning Dominic Ventresca Source Type: research
Social Connectedness Between Family Caregivers and Older Adults Living in Long-Term Care Homes in the Context of COVID-19
Can J Aging. 2023 Sep 20:1-12. doi: 10.1017/S0714980823000351. Online ahead of print.ABSTRACTThe coronavirus disease (COVID-19) pandemic and resulting restrictions on physical access to long-term care homes culminated in health declines for older adults living there and their families. Knowledge gaps exist regarding maintaining social connectedness when physically separated. The study aimed to explore family members' perceptions of the impact that restrictions on physical access to long-term care homes had on the experience of social connectedness between family members and older adults living in long-term care. The method...
Source: Canadian Journal on Aging - September 20, 2023 Category: Geriatrics Authors: Anna Garnett Hannah Pollock Natalie Floriancic Kristin Prentice Lorie Donelle Carri Hand Abe Oudshoorn Yolanda Babenko-Mould Cheryl Forchuk Source Type: research
The Pathogenesis of COVID-19-Related Taste Disorder and Treatments
J Dent Res. 2023 Sep 20:220345231182926. doi: 10.1177/00220345231182926. Online ahead of print.ABSTRACTCOVID-19, mainly manifested as acute respiratory distress syndrome, has afflicted millions of people worldwide since 2019. Taste dysfunction is a common early-stage symptom of COVID-19 infection that burdens patients for weeks or even permanently in some cases. Owing to its subjectivity and complexity, the mechanism of taste disorder is poorly studied. Previous studies have reported that the COVID-19 entry receptors are highly expressed in taste buds, thereby intensifying the cytocidal effect. Taste receptor cells are vul...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: J Wang R Liu H Ma W Zhang Source Type: research
Cinnamaldehyde inhibits cytokine storms induced by the ORF3a protein of SARS-CoV-2 via ROS-elimination in activated T cells
Phytother Res. 2023 Sep 19. doi: 10.1002/ptr.8016. Online ahead of print.ABSTRACTCytokine storms are the cause of complications in patients with severe COVID-19, and it becomes the target of therapy. Several natural compounds were selected to screen the inhibitory effect on T-cell proliferation by Fluorescence-Activated Cell Sorting (FACS) and cytokine production by enzyme-linked immunosorbent assay (ELISA). Open reading frame 3a (ORF3a) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) stimulates the specific T-cell activation model in vivo and in vitro. The coculture system included the macrophage cell line...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Jing Ma Xu Chen Rui Xue Fei Wang Jun Dong Ning Tao Zhihai Qin Source Type: research
